Abstract
Objectives: Limited data are available regarding the occurrence and the extent of cardiac rhythm disturbances in patients with COVID-19 treated with Remdesivir.
Methods: We present a case series of 52 patients who underwent daily electrocardiogram (ECG) examination after Remdesivir administration.
Results: Compared to baseline, a significant heart rate reduction was observed after initiation of Remdesivir; however, no case of severe bradycardia or arrhythmias leading to significant clinical complications or Remdesivir discontinuation occurred. Heart rate reduction was proportional to baseline heart rate values (r=0.75, p<0.001). By multivariate analysis, a less severe clinical presentation of Covid-19 (beta=0.47, p<0.01) was related to lower heart rate levels observed after Remdesivir administration.
Conclusions: Despite a significant reduction in heart rate observed after Remdesivir administration, no severe cardiovascular toxicity was observed in Covid-19 patients, even in the case of cardiovascular comorbidities.
Keywords: Cardiovascular Toxicity; Covid-19; Heart Rate; Remdesivir.
【저자키워드】 COVID-19, Remdesivir, heart rate, Cardiovascular Toxicity, 【초록키워드】 Remdesivir, Toxicity, ECG, arrhythmia, cardiovascular, Case series, heart, Patient, heart rate, Arrhythmias, patients, COVID-19 patients, Multivariate analysis, bradycardia, administration, Analysis, cardiac rhythm, reduction, cardiovascular comorbidities, examination, clinical complication, severe bradycardia, Occurrence, occurred, case sery, treated, less, reduction in, baseline, Limited, patients with COVID-19, was related, 【제목키워드】 Safety, heart rate, changes in, patients treated,