Abstract
Some viruses are known to be associated with increased apoptosis. Apoptotic cell death triggered by these viruses has a complex role in host antiviral immunity, and might facilitate the viral clearance or act as a mechanism for virus-induced tissue injury and disease progression. The induction of apoptosis is a hallmark of SARS-CoV-2 infection. Accumulating evidence suggests that there is a direct relationship between apoptosis rate and COVID-19 pathogenicity/severity. Targeting virus-induced apoptosis could be a promising strategy in the treatment of SARS-CoV-2 virus infection.
Keywords: Apoptosis; ORF3a; SARS-CoV; SARS-CoV-2.
All Keywords
【저자키워드】 SARS-CoV-2, Apoptosis, SARS-CoV, ORF3a, 【초록키워드】 COVID-19, Treatment, viruses, SARS-CoV-2, Apoptosis, SARS-COV-2 infection, SARS-CoV-2 virus, virus, viral clearance, Disease progression, Viral, ORF3a, virus infection, cell death, antiviral immunity, mechanism, Evidence, tissue injury, these viruses, complex, hallmark, SARS-CoV-2 virus infection, targeting, Host, Apoptotic cell death, facilitate, triggered, induction of apoptosis,
【저자키워드】 SARS-CoV-2, Apoptosis, SARS-CoV, ORF3a, 【초록키워드】 COVID-19, Treatment, viruses, SARS-CoV-2, Apoptosis, SARS-COV-2 infection, SARS-CoV-2 virus, virus, viral clearance, Disease progression, Viral, ORF3a, virus infection, cell death, antiviral immunity, mechanism, Evidence, tissue injury, these viruses, complex, hallmark, SARS-CoV-2 virus infection, targeting, Host, Apoptotic cell death, facilitate, triggered, induction of apoptosis,
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일부 바이러스는 세포 사멸 증가와 관련이 있는 것으로 알려져 있습니다. 이들 바이러스에 의해 촉발된 아폽토시스 세포 사멸은 숙주 항바이러스 면역에서 복잡한 역할을 하며 바이러스 제거를 촉진하거나 바이러스 유발 조직 손상 및 질병 진행의 메커니즘으로 작용할 수 있습니다. 세포자멸사 유도는 SARS-CoV-2 감염의 특징입니다. 축적된 증거는 세포자멸사 비율과 COVID-19 병원성/심각도 사이에 직접적인 관계가 있음을 시사합니다. 바이러스 유발 세포자멸사를 표적으로 하는 것은 SARS-CoV-2 바이러스 감염 치료에서 유망한 전략이 될 수 있습니다.
{{ 키워드: }} 아폽토시스; ORF3a; 사스-CoV; 사스 코로나바이러스 2.