Abstract
The current COVID-19 pandemic caused by SARS-CoV-2 has prompted investigators worldwide to search for an effective anti-viral treatment. A number of anti-viral drugs such as ribavirin, remdesivir, lopinavir/ritonavir, antibiotics such as azithromycin and doxycycline, and anti-parasite such as ivermectin have been recommended for COVID-19 treatment. In addition, sufficient pre-clinical rationale and evidence have been presented to use chloroquine for the treatment of COVID-19. Furthermore, Zn has the ability to enhance innate and adaptive immunity in the course of a viral infection. Besides, Zn supplement can favour COVID-19 treatment using those suggested and/or recommended drugs. Again, the effectiveness of Zn can be enhanced by using chloroquine as an ionophore while Zn inside the infected cell can stop SARS-CoV-2 replication. Given those benefits, this perspective paper describes how and why Zn could be given due consideration as a complement to the prescribed treatment of COVID-19.
Keywords: Anti-viral drugs; Chloroquine; Pneumocytes; RNA dependent RNA polymerase; SARS-CoV-2; Zinc transporter.
【저자키워드】 SARS-CoV-2, Chloroquine, RNA dependent RNA polymerase, Anti-viral drugs, Pneumocytes, zinc transporter, 【초록키워드】 COVID-19, Ivermectin, Treatment, viral infection, Zinc, Chloroquine, Lopinavir/ritonavir, Azithromycin, adaptive, Immunity, COVID-19 pandemic, Lopinavir, Ritonavir, drugs, Remdesivir, Antibiotics, complement, RNA dependent RNA polymerase, ribavirin, RNA, COVID-19 treatment, Viral, Effectiveness, doxycycline, SARS-CoV-2 replication, anti-viral drug, Ionophore, Evidence, Anti-viral drugs, Pneumocytes, Anti-viral treatment, treatment of COVID-19, Perspective, investigators, investigator, innate and adaptive immunity, infected cell, parasite, effective, ENhance, Course, caused, addition, suggested, 【제목키워드】 COVID-19, element, Can,