Abstract
The outbreak of the SARS-CoV-2 pandemic is triggering a global health emergency alert. Until vaccination becomes available, a bundle of effective preventive measures is desperately needed. Recent research is indicating the relevance of aerosols in the spread of SARS-CoV-2. Thus, in this study commercially available antiseptic mouthwashes based on the active ingredients chlorhexidine digluconate and octenidine dihydrochloride (OCT) were investigated regarding their efficacy against SARS-CoV-2 using the European Standard 14476. Based on the requirement of EN 14476 in which reduction of at least four decimal logarithms (≥4 log 10 ) of viral titre is requested to state efficacy, the OCT-based formulation was found to be effective within a contact time of only 15 s against SARS-CoV-2. Based on this in-vitro data the OCT mouthwash thus constitutes an interesting candidate for future clinical studies to prove its effectiveness in a potential prevention of SARS-CoV-2 transmission by aerosols.
Keywords: Antiviral; Coronavirus; Mouthwash; Octenidine dihydrochloride; SARS-CoV-2.
【저자키워드】 SARS-CoV-2, coronavirus, Antiviral, Mouthwash, Octenidine dihydrochloride, 【초록키워드】 SARS-CoV-2, Efficacy, vaccination, pandemic, Antiviral, SARS-CoV-2 pandemic, aerosol, Aerosols, Spread, SARS-CoV-2 transmission, outbreak, Research, Effectiveness, ingredient, Mouthwash, chlorhexidine, clinical study, Contact, octenidine, In-vitro, Standard, preventive measure, reduction, health emergency, Bundle, titre, logarithm, triggering, recent, European, effective, antiseptic mouthwashes, chlorhexidine digluconate, log, investigated, antiseptic mouthwashe, the SARS-CoV-2, 【제목키워드】 SARS-CoV-2, Efficacy, In-vitro, Standard, European,