Abstract
Severe diseases such as the ongoing COVID-19 pandemic, as well as the previous SARS and MERS outbreaks, are the result of coronavirus infections and have demonstrated the urgent need for antiviral drugs to combat these deadly viruses. Due to its essential role in viral replication and function, 3CL pro (main coronaviruses cysteine-protease) has been identified as a promising target for the development of antiviral drugs. Previously reported SARS-CoV 3CL pro non-covalent inhibitors were used as a starting point for the development of covalent inhibitors of SARS-CoV-2 3CL pro . We report herein our efforts in the design and synthesis of submicromolar covalent inhibitors when the enzymatic activity of the viral protease was used as a screening platform.
Keywords: 3CLpro; Mpro; SARS-CoV2; covalent inhibitors.
【저자키워드】 SARS-CoV2, 3CLpro, MPro, covalent inhibitors., 【초록키워드】 viruses, Coronavirus infection, SARS-CoV, COVID-19 pandemic, antiviral drugs, 3CL pro, 3CLpro, protease, MERS, inhibitors, antiviral drug, Replication, MPro, Coronavirus infections, Outbreaks, viral replication, inhibitor, synthesis, disease, platform, cysteine, starting point, enzymatic activity, inhibitors of SARS-CoV-2, effort, was used, reported, coronavirus, were used, in viral, demonstrated, 【제목키워드】 SARS-CoV-2, 3CL pro, in vitro, inhibitor,