Abstract
Objective: The aim of this systematic review and meta-analysis of randomized controlled trials(RCTs) was to investigate the efficacy of interferon (IFN)-β-containing regimens in treating patients with COVID-19.
Methods: PubMed, Embase, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov were searched from inception to 17 July 2021. RCTs comparing the clinical efficacy and safety of IFN-β-containing regimens (study group) to other antiviral treatment options or placebo (control group) in treating patients with COVID-19 were included.
Results: Eight RCTs were included. No significant difference in the 28-day all-cause mortality rate was observed between the study and control groups (OR, 0.74; 95% CI, 0.44-1.24; I 2 = 51%). The study groups had a lower rate of intensive care unit (ICU) admissions than the control groups (OR 0.58, 95% CI 0.36-0.95; I 2 = 0%). Furthermore, INF-β was not associated with an increased risk of any adverse event (AE) or serious AE when compared with the control group.
Conclusions: IFN-β does not appear to provide an increased survival benefit in hospitalized patients with COVID-19 but may help reduce the risk of ICU admission. Moreover, IFN-β is a safe agent for use in the treatment of COVID-19.
Keywords: COVID-19; ICU; SARS-CoV-2; interferon-β; mortality.
【저자키워드】 COVID-19, SARS-CoV-2, ICU, mortality., Interferon-β, 【초록키워드】 Treatment, Meta-analysis, Efficacy, Mortality, intensive care, intensive care unit, interferon, systematic review, risk, Antiviral treatment, hospitalized patients, RCT, Randomized, controlled trials, adverse event, ICU admission, Placebo, mortality rate, Admission, RCTs, Clinical efficacy, Safe, regimen, significant difference, control group, study group, 95% CI, no significant difference, increased risk, IFN-β, increased survival, help, ClinicalTrials, control groups, regimens, study groups, inception, benefit, serious AE, all-cause mortality rate, searched, hospitalized patient, reduce, Controlled, patients with COVID-19, with COVID-19, 【제목키워드】 Randomized controlled trial, Treatment, Meta-analysis, systematic review, clinical, Patient, Efficacy and safety, regimen,