Abstract
As the world desperately searches for ways to treat the coronavirus disease 2019 (COVID-19) pandemic, a growing number of people are turning to herbal remedies. The Artemisia species, such as A. annua and A. afra , in particular, exhibit positive effects against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection and COVID-19 related symptoms. A. annua is a source of artemisinin, which is active against malaria, and also exhibits potential for other diseases. This has increased interest in artemisinin’s potential for drug repurposing. Artemisinin-based combination therapies, so-called ACTs, have already been recognized as first-line treatments against malaria. Artemisia extract, as well as ACTs, have demonstrated inhibition of SARS-CoV-2. Artemisinin and its derivatives have also shown anti-inflammatory effects, including inhibition of interleukin-6 (IL-6) that plays a key role in the development of severe COVID-19. There is now sufficient evidence in the literature to suggest the effectiveness of Artemisia , its constituents and/or artemisinin derivatives, to fight against the SARS-CoV-2 infection by inhibiting its invasion, and replication, as well as reducing oxidative stress and inflammation, and mitigating lung damage.
Keywords: Artemisia; COVID-19; antiviral; artemisinins; drug repurposing.
【저자키워드】 COVID-19, Antiviral, drug repurposing., Artemisia, artemisinins, 【초록키워드】 Treatment, coronavirus disease, Drug repurposing, SARS-CoV-2, Inflammation, Coronavirus disease 2019, Anti-inflammatory effects, pandemic, severe COVID-19, Antiviral, IL-6, SARS-COV-2 infection, Infection, interleukin-6, severe acute respiratory syndrome coronavirus-2, oxidative stress, severe acute respiratory syndrome Coronavirus, Symptoms, Artemisinin, malaria, Replication, Severe acute respiratory syndrome, Effectiveness, Coronavirus-2, Evidence, Invasion, lung damage, acute respiratory syndrome, other diseases, acute respiratory syndrome coronavirus, combination therapies, acute respiratory syndrome coronavirus-2, treat, acts, derivative, positive, derivatives, Effect, shown, reducing, demonstrated, active against, inhibiting, exhibit, the SARS-CoV-2, 【제목키워드】 Extract,