Abstract
The lung is the major target organ of SARS-CoV-2 infection, which causes COVID-19. Here, we outline the multistep mechanisms of lung epithelial and endothelial injury induced by SARS-CoV-2: direct viral infection, chemokine/cytokine-mediated damage, and immune cell-mediated lung injury. Finally, we discuss the recent progress in terms of antiviral therapeutics as well as the development of anti-inflammatory or immunomodulatory therapeutic approaches. This review also provides a systematic overview of the models for studying SARS-CoV-2 infection and discusses how an understanding of mechanisms of lung injury will help identify potential targets for future drug development to mitigate lung injury.
Keywords: COVID-19; SARS-CoV-2; lung injury; lung organoid; therapeutics.
【저자키워드】 COVID-19, SARS-CoV-2, Therapeutics, Lung injury, lung organoid, 【초록키워드】 viral infection, Anti-inflammatory, Therapeutics, SARS-COV-2 infection, lung, Lung injury, chemokine, immune, immunomodulatory, target, antiviral therapeutics, endothelial injury, mechanism, target organ, therapeutic approaches, help, organ, direct viral infection, mitigate, lung epithelial, identify, provide, cause, 【제목키워드】 Lung injury, induced,