Abstract
The novel coronavirus disease has spread rapidly and caused sustained pressure on economic and medical resources to many countries. Vaccines and effective drugs are needed to fight against the epidemic. Traditional Chinese Medicine (TCM) plays an important and effective role in the treatment of COVID-19. Therefore, the active components of TCM are potential structural basis for the discovery of antiviral drugs. Through screening by molecular docking, Oleanolic acid, Tryptanthrin, Chrysophanol and Rhein were found to have better spike protein and ACE2 inhibitory activity, which could block the invasion and recognition of SARS-CoV-2 at the same time, should be investigated as antiviral candidates.
Keywords: ACE2; Dual antagonists; SARS-CoV-2; Spike glycoprotein.
【저자키워드】 SARS-CoV-2, ACE2, spike glycoprotein., Dual antagonists, 【초록키워드】 COVID-19, Treatment, coronavirus disease, Antiviral, spike, antiviral drugs, spike glycoprotein, molecular docking, Traditional Chinese medicine, novel coronavirus disease, Spike protein, Novel coronavirus, effective drugs, Spread, Medicine, glycoprotein, TCM, Invasion, Candidates, Recognition, treatment of COVID-19, Chinese, inhibitory activity, component, oleanolic acid, rhein, effective, medical resource, the epidemic, Chrysophanol, caused, investigated, sustained, effective drug, Traditional, 【제목키워드】 COVID-19, in silico, Screening, antagonist,