Abstract
Objectives: Our study aimed to assess the statistical relationship between the use of chloroquine phosphate or hydroxychloroquine plus azithromycin (CQ/HCQ + AZ) and virological recovery, disease worsening, and death among out- and inpatients with COVID-19 in Burkina Faso.
Methods and designs: This was a retrospective observational study that compared outcomes in terms of time to recovery, worsening, and death in patients who received CQ/HCQ + AZ and those who did not using a multivariable Cox or Poisson model before and after propensity matching.
Results: Of the 863 patients included in the study, about 50% (432/863) were home-based follow-up patients and 50% were inpatients. Of these, 83.3% (746/863) received at least 1 dose of CQ/HCQ + AZ and 13.7% (118/863) did not. There were no significant differences in associated time to recovery for patients receiving any CQ/HCQ + AZ (adjusted HR 1.44; 95% CI 0.76-2.71). Similarly, there was no significant association between CQ/HCQ + AZ use and worsening (adjusted IRR 0.80; 95% CI 0.50-1.50). However, compared with the untreated group, the treated group had a lower risk of death (adjusted HR 0.20; 95% CI 0.10-0.44).
Conclusions: The study provided valuable additional information on the use of CQ/HCQ in patients with COVID-19 and did not show any harmful outcomes of CQ/HCQ + AZ treatment.
Keywords: Aggravation; Burkina Faso; Fatality; SRAS-CoV-2; Viral clearance.
【저자키워드】 Burkina Faso, aggravation, SRAS-CoV-2, fatality, Viral clearance., 【초록키워드】 Treatment, Chloroquine, Azithromycin, Hydroxychloroquine, outcome, viral clearance, observational study, Chloroquine phosphate, Patient, death, Follow-up, aggravation, Time to recovery, information, disease, SRAS-CoV-2, association, fatality, retrospective, dose, phosphate, Inpatients, Inpatient, Virological, no significant differences, 95% CI, no significant difference, worsening, lower risk, clearance, statistical, multivariable, provided, receiving, treated, adjusted, hydroxychloroquine plus azithromycin, patients with COVID-19, Poisson model, with COVID-19, 【제목키워드】 assessment, Outpatient, Inpatient, time, with COVID-19,