Abstract
Coronavirus disease 2019 (COVID-19) is a life-threatening infectious respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 pandemic causing morbidities and even deaths worldwide revealed that there is urgent need to find pharmacological agents or vaccines. Although there are a lot of agents under investigation, there is no approved agent for the prevention or treatment of the COVID-19 yet. Treatment of patients remains mainly supportive as well as compassionate use of the agents under investigation. It is well established that excessive inflammatory and immune response and oxidative injury play a critical role in the pathogenesis of COVID-19. In this review, we aimed to update knowledge about pathogenesis, clinical features, and pharmacological treatment of COVID-19 and review the potential beneficial effects of ancient antioxidant, anti-inflammatory, and immunomodulatory molecule melatonin for prevention and treatment of COVID-19.
Keywords: COVID-19; anti-inflammatory; antioxidant; immunomodulatory; melatonin; renin-angiotensin system.
【저자키워드】 COVID-19, melatonin, Anti-inflammatory, antioxidant, renin-angiotensin system, immunomodulatory, 【초록키워드】 Treatment, coronavirus disease, SARS-CoV-2, Coronavirus disease 2019, coronavirus, immune response, Pathogenesis, melatonin, Anti-inflammatory, Vaccines, knowledge, COVID-19 pandemic, severe acute respiratory syndrome Coronavirus, antioxidant, Clinical features, renin-angiotensin system, immunomodulatory, Respiratory disease, morbidity, Patient, death, respiratory, Critical, compassionate use, angiotensin, Inflammatory, Injury, pharmacological treatment, acute respiratory syndrome, Renin, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, pharmacological agents, morbidities, life-threatening, pathogenesis of COVID-19, Effect, oxidative, caused, approved, pharmacological agent, 【제목키워드】 Treatment, Coronavirus disease 2019, melatonin,