Abstract
In this manuscript we provide the scientific basis to adopt a novel combination of two widely available nutraceuticals; resveratrol and zinc in management of COVID-19 recommending their administration using a nano-carrier based drug-delivery system. Resveratrol, a well-known antioxidant and anti-inflammatory triphenolic stilbene, is abundant in red grapes, red wine, dark chocolate, and peanut butter. Alternatively, pterostilbene-zinc combination might be also considered without using a nano-carrier. We recommend conducting prompt clinical trials to assess the potential of the suggested combinations as a monotherapy for mild COVID-19 with a potential to prevent its progression to moderate-severe disease for which we recommend their trial as an adjuvant therapy. Furthermore, the suggested combinations might also possess a pharmacotherapeutic potential that exceeds COVID-19 to various inflammatory, immunologic, and oncologic diseases.
Keywords: COVID-19; Drug delivery systems; Nanotechnology; Nutraceuticals; Pterostilbene; Resveratrol; Zinc.
【저자키워드】 COVID-19, Zinc, nutraceuticals, Nanotechnology, resveratrol, pterostilbene, drug delivery systems, 【초록키워드】 Zinc, clinical trial, therapy, Diseases, Trial, Anti-inflammatory, drug, progression, antioxidant, nutraceuticals, Nanotechnology, Red wine, management, Mild, resveratrol, pterostilbene, monotherapy, disease, Combination, administration, Inflammatory, adjuvant therapy, manuscript, Prevent, dark chocolate, peanut butter, suggested, moderate-severe, 【제목키워드】 therapy, Potential,