Abstract
Liver damage is observed in up to half of hospitalized COVID-19 patients and can result either from actions of SARS-CoV-2 as such or from pharmacological treatment. The present paper introduces an adverse outcome pathway construct that mechanistically describes the pathways induced by SARS-CoV-2 leading to liver injury. This can be caused by direct binding of the virus and local actions in cholangiocytes, but may also indirectly result from the general state of hypoxia and systemic inflammation in COVID-19 patients. Further research is urgently needed to fill remaining knowledge gaps. This will be anticipated to create a solid basis for future and more targeted development of vaccines and, in particular, therapies.
Keywords: AOP; COVID-19; Liver; Mechanism; SARS-CoV-2.
【저자키워드】 COVID-19, SARS-CoV-2, liver, mechanism, AOP, 【초록키워드】 SARS-CoV-2, Vaccine, hypoxia, knowledge, Local, virus, adverse outcome, Research, pathway, Liver injury, systemic inflammation, liver, mechanism, COVID-19 patients, Therapies, binding, hospitalized COVID-19 patient, Liver damage, Pathways, pharmacological treatment, hospitalized COVID-19 patients, caused, anticipated, 【제목키워드】 adverse outcome, pathway, Perspective,