Abstract
Severe COVID-19 is a biphasic illness, with an initial viral replication phase, followed by a cascade of inflammatory events. Progression to severe disease is predominantly a function of the inflammatory cascade, rather than viral replication per se. This understanding can be effectively translated to changing our approach in managing the disease. The natural course of disease offers us separate windows of specific time intervals to administer either antiviral or immunomodulatory therapy. Instituting the right attack at the right time would maximize the benefit of treatment. This concept must also be factored into studies that assess the efficacy of antivirals and immunomodulatory agents against COVID-19.
【초록키워드】 COVID-19, Treatment, Efficacy, severe COVID-19, Antiviral, Viral, viral replication, disease, immunomodulatory therapy, Immunomodulatory agents, Inflammatory, severe disease, Immunomodulatory agent, followed by, time interval, time intervals, cascade, offer, inflammatory cascade, approach, benefit, initial, Course, the disease, events, translated, administer, 【제목키워드】 treating,