Abstract
Since its outbreak, the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has impacted the quality of life and cost hundreds-of-thousands of lives worldwide. Based on its global spread and mortality, there is an urgent need for novel treatments which can combat this disease. To date, the 3-chymotrypsin-like protease (3CL pro ), which is also known as the main protease, is considered among the most important pharmacological targets. The vast majority of investigated 3CL pro inhibitors are organic, non-covalent binders. Herein, the use of inorganic, coordinate covalent binders is proposed that can attenuate the activity of the protease. Re I tricarbonyl complexes were identified that demonstrate coordinate covalent enzymatic inhibition of 3CL pro . Preliminary studies indicate the selective inhibition of 3CL pro over several human proteases. This study presents the first example of metal complexes as inhibitors for the 3CL pro cysteine protease.
Keywords: SARS-CoV-2; antiviral agents; bioinorganic chemistry; medicinal inorganic chemistry; protease inhibitor.
【저자키워드】 SARS-CoV-2, Protease inhibitor, Antiviral agents, bioinorganic chemistry, medicinal inorganic chemistry, 【초록키워드】 Treatment, Mortality, Antiviral, 3CL pro, protease, inhibitors, Protease inhibitor, Spread, Severe acute respiratory syndrome, outbreak, Antiviral agents, Quality of life, targets, Proteases, inhibitor, disease, life, cysteine, selective inhibition, cysteine protease, chymotrypsin, selective, pharmacological, inorganic, Inorganic chemistry, example, investigated, majority, complexes, impacted, attenuate, 【제목키워드】 Coordinate, the SARS-CoV-2,