Abstract
Objective: We systematically reviewed the evidence of published original research to determine the role of remdesivir in the management of patients with COVID-19 and a moderate-to-severe course of illness.
Methods: A systematic search of articles was conducted in scientific databases, with the latest update in May 2021. This paper systematically reviewed the clinical evidence available (randomized controlled trials, compassionate use studies, and case reports) on the use of remdesivir for patients with moderate or severe COVID-19.
Results: A total of eleven studies were included: four studies based on compassionate use of remdesivir, three randomized, double-blind, placebo-controlled, multicentre trials, three randomized, open-label, phase III trials, and one case report. Clinical improvement and mortality rates in patients who used remdesivir varied across studies.
Conclusion: Given the current evidence, there is insufficient data to confidently recommend the use of remdesivir alone for the treatment of adult hospitalized patients with moderate-to-severe COVID-19. However, remdesivir may be considered along with an anti-inflammatory agent in patients with pneumonia, on oxygen support, provided there is close monitoring of clinical and laboratory parameters and adverse events.
Keywords: Adverse events; SARS-CoV-2; critically ill; evidence-based medicine; remdesivir.
【저자키워드】 SARS-CoV-2, adverse events, remdesivir., Critically ill, Evidence-based medicine, 【초록키워드】 Treatment, Randomized controlled trials, Open-label, severe COVID-19, Remdesivir, oxygen, Case report, adverse events, Randomized, Critically ill, controlled trials, clinical, management, Evidence-based medicine, Research, Patient, Laboratory parameters, Placebo, Phase III trials, multicentre, mortality rate, mortality rates, trials, placebo-controlled, compassionate use, Evidence, double-blind, evidence of, anti-inflammatory agent, Adverse, moderate-to-severe COVID-19, clinical and laboratory parameters, article, clinical evidence, oxygen support, close monitoring, laboratory parameter, Course, conducted, provided, determine, hospitalized patient, patients with COVID-19, patients with moderate, patients with pneumonia, 【제목키워드】 systematic review, management, Patient,