Abstract
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) currently poses a threat to human health. 3C-like proteinase (3CLpro) plays an important role in the viral life cycle. Hence, it is considered an attractive antiviral target protein. Whole-genome sequencing showed that the sequence homology between SARS-CoV-2 3CLpro and SARS-CoV 3CLpro is 96.08%, with high similarity in the substrate-binding region. Thus, assessing peptidomimetic inhibitors of SARS-CoV 3CLpro could accelerate the development of peptidomimetic inhibitors for SARS-CoV-2 3CLpro. Accordingly, we herein discuss progress on SARS-CoV-2 3CLpro peptidomimetic inhibitors. Inflammation plays a major role in the pathophysiological process of COVID-19. Small-molecule compounds targeting 3CLpro with both antiviral and anti-inflammatory effects are also briefly discussed in this paper.
Keywords: 3CLpro; SARS-CoV; SARS-CoV-2; anti-inflammatory agents; peptidomimetics; protease inhibitors; small-molecule inhibitors.
【저자키워드】 SARS-CoV-2, SARS-CoV, 3CLpro, protease inhibitors, peptidomimetics, anti-inflammatory agents, small-molecule inhibitors., 【초록키워드】 COVID-19, coronavirus disease, whole-genome sequencing, Coronavirus disease 2019, coronavirus, Anti-inflammatory effects, Anti-inflammatory, Antiviral, Sequencing, 3CLpro, protease, severe acute respiratory syndrome Coronavirus, inhibitors, protease inhibitors, Protein, Health, inhibitor, antiviral target, anti-inflammatory agents, similarity, life cycle, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, Compound, sequence homology, viral life cycle, anti-inflammatory effect, proteinase, caused, accelerate, pathophysiological, 【제목키워드】 Compound, inspiration, Progress,