Abstract
We hypothesize that polycations, such as nuclear histones, released by neutrophils COVID-19 aggravate COVID-19 by multiple mechanisms: (A) Neutralization of the electrostatic repulsion between the virus particles and the cell membrane, thereby enhancing receptor-mediated entry. (B) Binding to the virus particles, thereby inducing opsonin-mediated endocytosis. (C) Adding to the cytotoxicity, in conjunction with oxidants, cytokines and other pro-inflammatory substances secreted by cells of the innate immunity system. These effects may be alleviated by the administration of negatively charged polyanions such as heparins and heparinoids.
Keywords: COVID-19; Heparin; Neutrophils; Polyanions; Polycations; SARS-CoV-2; Therapy.
【저자키워드】 COVID-19, Neutrophils, SARS-CoV-2, therapy, heparin, polyanions, Polycations, 【초록키워드】 Neutrophils, Cytokines, Innate immunity, neutrophil, cytotoxicity, cytokine, heparin, administration, the cell, Histones, conjunction, heparins, virus particles, cell membrane, nuclear, electrostatic repulsion, pro-inflammatory, Effect, Cell, oxidants, opsonin, virus particle, released, aggravate, Adding, secreted, 【제목키워드】 SARS-COV-2 infection,