Abstract
The outbreak of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected the entire world with its infectious spread and mortality rate. The severe cases of coronavirus disease 2019 (COVID-19) are characterized by hypoxia and acute respiratory distress syndrome. In the absence of any specific treatment, just the preventive and supportive care options are available. Therefore, much focus is given to assess the available therapeutic options not only to avoid acute respiratory failure and hypoxia but also to reduce the viral load to control the severity of the disease. The antimalarial drug hydroxychloroquine (HCQ) is among the much-discussed drugs for the treatment and management of COVID-19 patients. This article reviews the therapeutic potential of HCQ in the treatment of COVID-19 based on the available in vitro and clinical evidence, current status of registered HCQ-based clinical trials investigating therapeutic options for COVID-19, and environmental implications of HCQ.
Keywords: COVID-19; Clinical trials; Environmental implications; Hydroxychloroquine; Pandemic; SARS-CoV-2; Treatment.
【저자키워드】 COVID-19, Treatment, SARS-CoV-2, pandemic, Hydroxychloroquine, clinical trials, Environmental implications, 【초록키워드】 Treatment, coronavirus disease, Coronavirus disease 2019, coronavirus, clinical trial, Respiratory failure, Hydroxychloroquine, acute respiratory distress syndrome, hypoxia, severity, Acute respiratory failure, drug, in vitro, antimalarial, Spread, Viral load, outbreak, clinical, management, severe cases, HCQ, mortality rate, COVID-19 patients, therapeutic options, acute respiratory distress, supportive care, therapeutic option, respiratory distress, antimalarial drug, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, therapeutic potential, syndrome, Registered, Severe case, clinical evidence, specific treatment, implication, affected, the disease, characterized, absence, reduce, 【제목키워드】 Hydroxychloroquine, therapeutic, implication,