Abstract
Objective: Severe acute respiratory syndrome coronavirus 2 (SARS-COV2) was first detected in Wuhan, China in December, 2019. The emerging virus causes a respiratory illness, that can trigger a cytokine storm in the body.
Method: Cytokine storm in patient’s body is associated with severe forms of disease. It is one of the main complications of coronavirus disease-2019 (COVID-19), in which immune cells play a major role. Studies have shown immune cells in the tumor environment can be effective to induce resistance to chemotherapy in cancer patients.
Result: Therefore, considering the role of immune cells to induce cytokine storm in COVID-19 patients, and their role to cause resistance to chemotherapy, they are effective on disease progression and creation of severe form of disease.
Conclusion: By examining the signaling pathways and inducing resistance to chemotherapy in tumor cells and the cells affect them, it is possible to prevent the occurrence of severe forms of the disease in cancer patients with COVID-19; it is applicable using target therapy and other subsequent treatment strategies.
Keywords: COVID-19; Chemotherapy resistance; Cytokine storm; Pathogenesis.
【저자키워드】 COVID-19, Cytokine storm, pathogenesis., Chemotherapy resistance, 【초록키워드】 coronavirus disease, severe acute respiratory syndrome coronavirus 2, Tumor, Cytokine storm, coronavirus, therapy, Pathogenesis, Respiratory illness, severe acute respiratory syndrome Coronavirus, virus, coronavirus disease-2019, Chemotherapy, Disease progression, Wuhan, Patient, Cancer patients, Complication, immune cells, signaling pathway, disease, signaling pathways, COVID-19 patients, Chemotherapy resistance, Immune cell, tumor cells, cancer patient, acute respiratory syndrome, Treatment strategies, creation, acute respiratory syndrome coronavirus, Affect, Prevent, effective, Cell, Wuhan, China, Occurrence, shown, subsequent, the disease, form, induce, cause, tumor cell, 【제목키워드】 cancer cell,