Abstract
Cardiovascular adverse conditions are caused by coronavirus disease 2019 (COVID-19) infections and reported as side-effects of the COVID-19 vaccines. Enriching current vaccine safety surveillance systems with additional data sources may improve the understanding of COVID-19 vaccine safety. Using a unique dataset from Israel National Emergency Medical Services (EMS) from 2019 to 2021, the study aims to evaluate the association between the volume of cardiac arrest and acute coronary syndrome EMS calls in the 16-39-year-old population with potential factors including COVID-19 infection and vaccination rates. An increase of over 25% was detected in both call types during January-May 2021, compared with the years 2019-2020. Using Negative Binomial regression models, the weekly emergency call counts were significantly associated with the rates of 1st and 2nd vaccine doses administered to this age group but were not with COVID-19 infection rates. While not establishing causal relationships, the findings raise concerns regarding vaccine-induced undetected severe cardiovascular side-effects and underscore the already established causal relationship between vaccines and myocarditis, a frequent cause of unexpected cardiac arrest in young individuals. Surveillance of potential vaccine side-effects and COVID-19 outcomes should incorporate EMS and other health data to identify public health trends (e.g., increased in EMS calls), and promptly investigate potential underlying causes.
【초록키워드】 COVID-19, coronavirus disease, public health, Coronavirus disease 2019, Vaccine, COVID-19 vaccine, Infection, outcome, Cardiac arrest, cardiovascular, vaccine dose, COVID-19 vaccines, Health, Surveillance, COVID-19 infection, myocarditis, age, dataset, association, Acute coronary syndrome, Emergency, causal relationship, causal relationships, Side-effects, Volume, Factor, Side-effect, infection rates, causes, regression models, service, while, vaccination rates, binomial, negative, Administered, raise, IMPROVE, identify, evaluate, caused, significantly, reported, condition, unique, individuals, coronary syndrome, with COVID-19, 【제목키워드】 COVID-19, Vaccine, Increased, cardiovascular event,