Abstract
Purpose of review: To investigate the possible effects of severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) on kidney function and assess the rate of viral ribonucleic acid (RNA) shedding/detection in urine.
Recent findings: Most of the research on the topic suggests that for the moment our ability to estimate whether SARS-CoV-2 is a direct causative agent in acute kidney injury (AKI) or whether it has a cytokine storm effect is limited. During our prospective assessment of 333 patients with COronaVIrus Disease 2019 (COVID-19) it was found that frequency of AKI of 9.6% (32 cases). Despite previous data suggestive of the ability to detect SARS-CoV-2 in urine, we were unable to identify any traces of messenger ribonucleic acid (mRNA) in our group. Both COVID-19 severity (odds ratio, OR = 23.09, confidence interval, CI 7.89-67.57, P < 0.001) and chronic kidney disease (CKD) history (OR = 7.17, CI 2.09-24.47, P = 0.002) were associated with the AKI rate.
Summary: AKI is a relatively frequent condition for patients with COVID-19 and is normally correlated with the severity of the disease and the patient’s history of CKD. The available data fail to address whether SARS-CoV-2 mRNA is present in urine, whereas our prospective trial data suggest that mRNA is undetectable in urine irrespective of the severity of the disease.
【초록키워드】 COVID-19, coronavirus disease, SARS-CoV-2, Coronavirus disease 2019, Cytokine storm, coronavirus, Kidney function, severity, COVID-19 severity, Acute kidney injury, Chronic kidney disease, coronavirus 2, RNA, Severe acute respiratory syndrome, AKI, mRNA, Research, Patient, Kidney disease, Urine, Severe acute respiratory syndrome-related coronavirus, Frequency, Odds ratio, CKD, Ribonucleic acid, causative agent, in urine, Prospective trial, confidence interval, acute respiratory syndrome, Topic, available data, moment, viral ribonucleic acid, MOST, Effect, recent, identify, detect, the patient, the disease, correlated, patients with COVID-19, undetectable, 【제목키워드】 Kidney injury, kidney, AKI, Viral RNA, patients with COVID-19,