Abstract
Continuously emerging variants of concern (VOCs) sustain the SARS-CoV-2 pandemic. The SARS-CoV-2 Omicron/B.1.1.529 VOC harbours multiple mutations in the spike protein associated with high infectivity and efficient evasion from humoral immunity induced by previous infection or vaccination. By performing in-depth comparisons of the SARS-CoV-2-specific T-cell epitope repertoire after infection and messenger RNA vaccination, we demonstrate that spike-derived epitopes were not dominantly targeted in convalescent individuals compared to non-spike epitopes. In vaccinees, however, we detected a broader spike-specific T-cell response compared to convalescent individuals. Booster vaccination increased the breadth of the spike-specific T-cell response in convalescent individuals but not in vaccinees with complete initial vaccination. In convalescent individuals and vaccinees, the targeted T-cell epitopes were broadly conserved between wild-type SARS-CoV-2 variant B and Omicron/B.1.1.529. Hence, our data emphasize the relevance of vaccine-induced spike-specific CD8 + T-cell responses in combating VOCs including Omicron/B.1.1.529 and support the benefit of boosting convalescent individuals with mRNA vaccines.
【초록키워드】 SARS-CoV-2, vaccination, pandemic, VoC, SARS-CoV-2 pandemic, T-cell Response, variant, Infection, variants of concern, omicron, CD8, Spike protein, mRNA vaccines, spike-specific T-cell response, Epitopes, Humoral immunity, comparison, VOCs, T-cell, T-cell epitopes, epitope, T-cell epitope, breadth, booster vaccination, Support, Messenger RNA, wild-type SARS-CoV-2, multiple mutations, vaccinees, convalescent individuals, Complete, benefit, vaccinee, combating, initial, convalescent individual, conserved, the spike protein, multiple mutation, the SARS-CoV-2, 【제목키워드】 T-cell, convalescent, individual,