Abstract
Coronaviruses can have a devastating impact on the health of humans and animals. Porcine epidemic diarrhea virus (PEDV) causes extremely high fatality rates in neonatal piglets, whereas severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the current COVID-19 pandemic in humans. As a critical component of the host antiviral innate immune response, type I interferon production and signaling play a very important role, especially in the initial phase of the antiviral responses. Coronaviruses have evolved multiple ways to counteract type I interferon responses. Although the primary functions of the nucleocapsid protein are to facilitate viral RNA replication and package viral genomic RNA into virions, recent studies have shown that the nucleocapsid protein is also involved in virus-host interactions. The aim of this review is to summarize our current understanding of how the nucleocapsid proteins of PEDV and SARS-CoV-2 modulate type I interferon responses. This knowledge will be useful for developing strategies to combat coronavirus infections.
【초록키워드】 SARS-CoV-2, coronavirus, innate immune response, Antiviral, knowledge, COVID-19 pandemic, Human, severe acute respiratory syndrome Coronavirus, diarrhea, virus, type I interferon, nucleocapsid protein, Replication, Coronavirus infections, Health, animals, humans, Virus-host interactions, Viral RNA, antiviral responses, Critical, function, Signaling, genomic RNA, Neonatal, epidemic diarrhea, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, Fatality rate, Nucleocapsid proteins, PEDV, viral genomic RNA, virions, Host, responses, initial, shown, responsible, involved, facilitate, modulate, cause, 【제목키워드】 Alpha, modulation, Host, betacoronavirus,