Abstract
Excessive prostaglandin E 2 (PGE 2 ) is the key pathological basis for COVID-19 and a Celebrex treatment of hospitalized COVID-19 patients with comorbidities led to 100% discharged rate and zero death (Hong et al. 2020). It is also suggested that SARS-CoV-2 infected multiple organs and the SARS-CoV nucleocapsid (N) protein transcriptionally drives the expression of the host COX-2 gene. In order to test whether SARS-CoV-2 N protein activates COX-2 transcription in multiple human relevant cell types, an expression inducible human embryonic stem cell line was generated by piggyBac transposon system. This cell line maintained its pluripotency, differentiation potentials, normal morphology and karyotype.
【초록키워드】 COVID-19, Treatment, SARS-CoV-2, SARS-CoV, Transcription, Comorbidities, Comorbidity, Protein, nucleocapsid, death, SARS-CoV-2 N protein, morphology, expression, hospitalized COVID-19 patient, stem cell, cell types, embryonic stem cell, prostaglandin, hospitalized COVID-19 patients, multiple organs, cell line, karyotype, Host, celebrex, prostaglandin E, suggested, activate, discharged, embryonic, transposon, multiple organ, PGE, transcriptionally, 【제목키워드】 nucleocapsid protein, expression, cell line, Generation, embryonic, the SARS-CoV-2,