Abstract
Introduction: To assess the risk for COVID-19 of police officers, we are studying the seroprevalence in a cohort. The baseline cross-sectional investigation was performed before a vaccination campaign in January/February 2021, and demonstrated a seroprevalence of 12.9%. Here, we demonstrate serosurveillance results after a vaccination campaign.
Methods: The cohort consists of 1022 study participants. The 3- and 6-month follow-up visits were performed in April/May and September 2021. Data on infection and vaccination rates were obtained via measuring antibodies to the nucleocapsid protein and spike protein and online questionnaires.
Results: The mean age of the population was 41 (SD 8.8) years, 72% were male and 76% had no comorbidity. Seroconversion was identified in 1.05% of the study population at the 3-month visit and in 0.73% at the 6-month visit, resulting in an infection rate of 1.8% over a time period of 6 months. In comparison, the infection rate in the general population over the same time period was higher (3.18%, p = .018). At the 6-month visit, 77.8% of participants reported being vaccinated once and 70.5% twice; 81% had an anti-S antibody titer of >250 U/ml and 87.1% of ≥2 U/ml. No significant association between infection and job role within the department, working region, or years of experience in the job was found. Anti-spike antibody titers of vaccinated study participants showed a calculated decreasing trend 150-200 days after the second vaccine dose.
Conclusion: These data confirm the value of the vaccination campaign in an exposed group other than healthcare professionals.
Keywords: COVID-19 seroprevalence; SARS-CoV-2; anti-NCP-antibodies; anti-S-antibodies.
【저자키워드】 SARS-CoV-2, COVID-19 seroprevalence, anti-NCP-antibodies, anti-S-antibodies., 【초록키워드】 COVID-19, vaccination, antibody, cross-sectional, healthcare professionals, Seroprevalence, Infection, Comorbidity, risk, Spike protein, nucleocapsid protein, vaccine dose, Cohort, Seroconversion, male, Antibody titer, age, General population, infection rate, anti-spike antibody, association, study population, These data, Study participants, online questionnaires, participant, U/mL, Department, vaccination rates, vaccination rate, anti-S antibody, Follow-up visit, resulting, performed, reported, was performed, calculated, demonstrated, had no, study participant, baseline, 【제목키워드】 COVID-19 vaccine,