Abstract
Introduction: Coronavirus disease is associated with increased morbidity and mortality in maintenance hemodialysis (MHD) patients. Recent breakthrough infection in vaccinated people has led some authorities to recommend a booster dose for patients fully vaccinated 5-8 months ago. We aimed to assess the humoral response of MHD patients following a booster dose with the BNT162b2 vaccine.
Methods: The study included 102 MHD patients vaccinated with 2 doses of the BNT162b2 (Pfizer-BioNTech) vaccine. A third dose (booster) was recommended to all MHD patients in our center and was given to those who opted to receive it, resulting in a booster group and a control group that did not receive the booster. Previous exposure was excluded by testing for the presence of the anti-nucleocapsid antibody (SARS-CoV-2) or positive PCR. We assessed the humoral response before and after the booster dose.
Results: Of 66 patients in the booster group, 65 patients (98.5%) developed a positive antibody response, from 472.7 ± 749.5 to 16,336.8 ± 15,397.3, as compared to a sustained decrease in the control group (695.7 ± 642.7 to 383.6 ± 298.6), p < 0.0001. No significant adverse effects were reported. Prior antibody titers were positively correlated to IgG levels following the booster dose. There was a significant association between malnutrition-inflammation markers and the humoral response.
Conclusions: Almost all MHD patients developed a substantial humoral response following the booster dose, which was significantly higher than levels reported for MHD patients following administration of 2 doses alone. Further studies and observations are needed to determine the exact timing and dosing schedule.
Keywords: COVID-19 vaccine; COVID-19 virus; Hemodialysis.
【저자키워드】 COVID-19 vaccine, COVID-19 virus, Hemodialysis., 【초록키워드】 COVID-19, coronavirus disease, SARS-CoV-2, observations, Vaccine, BNT162b2 vaccine, COVID-19 vaccine, antibody, BNT162b2, Hemodialysis, Humoral response, Patient, Antibody titer, COVID-19 virus, morbidity and mortality, Breakthrough infection, Malnutrition, disease, booster dose, patients, Pfizer-BioNTech, inflammation markers, Antibody titers, booster, association, marker, administration, dose, Maintenance hemodialysis, humoral, observation, adverse effect, control group, IgG levels, positive PCR, positive antibody response, recent, decrease, resulting, reported, determine, significantly higher, excluded, sustained, receive, IgG level, positively correlated, 【제목키워드】 Pfizer, response, maintenance,