Abstract
Background: The rate of severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) infection and immunogenicity of a single dose of ChAdOx1 vaccine at 16 weeks post-vaccination among young and healthy participants remains unclear in Saudi Arabia.
Objectives: Assess the rate of subsequent infection and immunogenicity of a single dose of ChAdOx1 vaccine at 16 weeks post-vaccination in a sample of healthy and young participants.
Design: Cross-sectional study SETTING: Academic teaching hospital in Riyadh, Saudi Arabia SUBJECTS AND METHODS: Healthy participants 18-50 years of age, who received one dose of ChAdOx1 vaccine and had no history of SARS CoV-2 infection were recruited, and blood samples were obtained 16 weeks after vaccination to assess immunogenicity using a commercially available kit.
Main outcome measures: The rate of SARS-CoV-2 infection within 16 weeks post-vaccination.
Sample size: 385 participants with median (IQR) age of 34 (29-38) years.
Results: Eleven (2.8%) participants acquired polymerase chain reaction (PCR)-confirmed infection within 16 weeks after a single dose of ChAdOx1 vaccine (mean [SD] 42.5 [28] days post-vaccination). No hospital or intensive care unit admissions occurred among the subjects in this sample. Females were significantly over-represented in PCR-confirmed cases of SARS-CoV-2 infection, with 10 of 11 infections occurring in females ( P =.006). Antibody response against anti-spike IgG were detectable in 92.7% of subjects at 16 weeks’ post-vaccination. The median anti-spike IgG level after vaccination was 273.1 (IQR 107-1052 AU/mL). However, the anti-nucleocapsid IgG antibody demonstrated a sensitivity of only 20%.
Conclusion: A single dose of ChAdOx1 vaccine in healthy and young individuals was associated with a low, single-digit rate of PCR-confirmed infection, most of which were mild.
Limitations: Small sample size and single-center.
Conflict of interest: None.
【초록키워드】 SARS CoV-2, coronavirus, vaccination, immunogenicity, intensive care, antibody, SARS-COV-2 infection, hospital, Antibody Response, Infection, outcome, severe acute respiratory syndrome Coronavirus, Saudi Arabia, polymerase chain reaction, sensitivity, cross-sectional study, anti-Spike IgG, female, Mild, age, ChAdOx1 vaccine, Admission, conflict, ChAdOx1, single dose, dose, Chain Reaction, SARS CoV-2 infection, acute respiratory syndrome, Participants, Sample size, conflict of interest, acute respiratory syndrome coronavirus, PCR-confirmed, acute respiratory syndrome coronavirus 2, Blood samples, subject, SARS CoV, individual, blood sample, single-center, participant, small sample size, anti-Nucleocapsid IgG, polymerase chain, Sample, occurred, significantly, healthy, recruited, subsequent, detectable, median, demonstrated, had no, anti-spike IgG level, IQR, 【제목키워드】 healthy,