Abstract
The disease spectrum of coronavirus disease 2019 (COVID-19) ranges from no symptoms to multisystem failure and death. Characterization of virus-specific immune responses to severe acute respiratory coronavirus 2 (SARS-CoV-2) is key to understanding disease pathogenesis, but few studies have evaluated T cell immunity. In this issue of the JCI, Sattler and Angermair et al. sampled blood from subjects with COVID-19 and analyzed the activation and function of virus antigen-specific CD4+ T cells. T cells that failed to respond to peptides from the membrane, spike, or nucleocapsid proteins were more common in subjects who died. In those whose T cells had the capacity to respond, older patients with comorbidity had larger numbers of activated T cells compared with patients who had fewer risk factors, but these cells showed impaired IFN-γ production. This cross-sectional study relates activated T cell responses to patient risk factors and outcome. However, T cell response trajectory over the disease course remains an open question.
【초록키워드】 COVID-19, coronavirus disease, SARS-CoV-2, Coronavirus disease 2019, coronavirus, immune response, Risk factors, Immunity, T cells, cross-sectional, peptide, Comorbidity, outcome, risk factor, virus, nucleocapsid protein, T cell, older patient, cross-sectional study, immune responses, Patient, peptides, death, membrane, trajectory, CD4+ T cells, respiratory, T cell response, Blood, IFN-γ, older patients, open, no symptoms, characterization, Disease spectrum, disease pathogenesis, Activation, no symptom, subject, These cells, severe acute respiratory coronavirus, disease course, Nucleocapsid proteins, activated T cells, Respiratory Coronavirus, Course, analyzed, died, the disease, evaluated, activated, question, respond, these cell, activated T cell, with COVID-19, 【제목키워드】 T cells, risk,