Abstract
This minireview addresses problems of financing the vaccine development, regulatory questions, the ethics and efficacy of vaccine prioritization strategies and the coverage of variant viruses by current vaccines. Serious adverse effects observed with adenovirus vectored vaccines and mRNA vaccines in mass vaccination campaigns are reported. The ethical problems of continuing with placebo controlled vaccine trials and alternative clinical trial protocols are discussed as well as concrete vaccination issues such as the splitting of doses, the delaying of the second dose, the immunization with two different vaccine types and the need of vaccinating seropositive subjects. Strategies to increase vaccine acceptance in the population are shortly mentioned.
【초록키워드】 Efficacy, Vaccine, Vaccine development, vaccination, clinical trial, protocol, Vaccines, mRNA vaccine, variant, Strategy, Ethics, virus, immunization, mRNA vaccines, Adenovirus, Regulatory, Coverage, Placebo, mass vaccination, adverse effect, problems, second dose, problem, doses, seropositive subjects, vaccine trial, splitting, reported, the vaccine, adenovirus vectored vaccine, 【제목키워드】 vaccination, problem,