Abstract
Coronavirus disease (COVID-19) is an infectious disease caused by a newly discovered coronavirus that it disease spreads in over the world. Coronaviruses are single-stranded, positive-sense RNA viruses with a genome of approximately 30 KD, the largest genome among RNA viruses. Most people infected with the COVID-19 virus will experience mild to moderate respiratory illness and recover without requiring special treatment. Older people and those with underlying medical problems like cardiovascular disease, diabetes, chronic respiratory disease, and cancer are more likely to develop serious illness. At this time, there are no specific vaccines or treatments for COVID-19. So, there is an emergency need for vaccines and antiviral strategies. The spike protein is the major surface protein that it uses to bind to a receptor of another protein that acts as a doorway into a human cell. The putative antigenic epitopes may prove effective as novel vaccines for eradication and combating of COV19 infection. A combination of available bioinformatics tools are used to synthesis of such peptides that are important for the development of a vaccine. In conclusion, amino acids 250-800 were selected as effective B cell epitopes, T cell epitopes, and functional exposed amino acids in order to a recombinant vaccine against coronavirus.
Keywords: SARS-CoV-2/COVID-19; Spike protein; T and B cell epitopes prediction; Vaccine design.
【저자키워드】 Vaccine design, Spike protein, SARS-CoV-2/COVID-19, T and B cell epitopes prediction, 【초록키워드】 COVID-19, Treatment, coronavirus disease, viruses, Vaccine, coronavirus, spike, Cancer, Vaccine design, Genome, bioinformatics, Infection, peptide, Respiratory illness, cardiovascular disease, Infectious disease, diabetes, Spike protein, Protein, Epitopes, T cell, RNA viruses, Respiratory disease, peptides, amino acids, COVID-19 virus, Mild, eradication, positive-sense RNA viruses, receptor, RNA virus, respiratory, disease spread, disease, moderate, Amino acid, Combination, B cell epitopes, B cell epitope, T cell epitopes, mild to moderate, recombinant vaccine, Antiviral strategies, problem, novel vaccines, chronic respiratory disease, MOST, human cell, surface protein, effective, single-stranded, positive-sense, combating, selected, develop, caused, functional, antigenic epitope, treatments for COVID-19, 【제목키워드】 S protein, Epitopes, amino acids, vaccine candidate, epitope, Amino acid, identification, functional,