Abstract
This paper aims to summarize through meta-analyses the overall vaccine effectiveness of the BNT162b2 mRNA vaccine from observational studies. A systematic literature search with no language restriction was performed in electronic databases to identify eligible observational studies which reported the adjusted effectiveness of the BNT162b2 mRNA vaccine to prevent RT-PCR confirmed COVID-19. Meta-analyses with the random-effects model were used to calculate the pooled hazard ratio (HR) and pooled incidence rate ratio (IRR) at 95% confidence intervals, and the vaccine effectiveness was indicated as (pooled HR – 1)/HR or (pooled IRR – 1)/IRR. Nineteen studies were included for this meta-analysis. The meta-analysis revealed significant protective effect against RT-PCR confirmed COVID-19 ≥ 14 days after the first dose, with vaccine effectiveness of 53% (95% confidence interval 32-68%), and ≥ 7 days after the second dose, with vaccine effectiveness of 95% (95% confidence interval: 96-97%). Despite its effectiveness, reporting vaccine safety data by relevant stakeholders should be encouraged as BNT162b2 mRNA is a new vaccine that has not gained full approval. There have been limited data about vaccine effectiveness among immunocompromised patients; thus, the vaccine should be used cautiously in this patient population.
Keywords: BNT162b2; COVID-19; Real world; SARS-CoV-2; Vaccine.
【저자키워드】 COVID-19, SARS-CoV-2, Vaccine, BNT162b2, Real world, 【초록키워드】 Meta-analysis, Vaccine, Immunocompromised patients, RT-PCR, database, observational studies, observational study, BNT162b2, Effectiveness, incidence rate, Immunocompromised, protective effect, BNT162b2 mRNA, BNT162b2 mRNA vaccine, meta-analyses, rate ratio, Confidence intervals, 95% confidence interval, second dose, hazard ratio, first dose, approval, random-effects model, systematic literature search, patient population, Prevent, identify, reported, indicated, was performed, adjusted, were used, the vaccine, calculate, eligible, 【제목키워드】 observational study, mRNA, Effectiveness, of BNT162b2,