Abstract
Currently, there is no widely acceptable and proven effective treatment for coronavirus disease 2019 (COVID-19). Colchicine has been shown to offer a benefit in reducing the inflammation in several inflammatory diseases. This study aims to analyze the efficacy of colchicine administration and outcomes of COVID-19. We systematically searched the PubMed and Europe PMC database using specific keywords related to our aims until January 29, 2021. All articles published on COVID-19 and colchicine treatment were retrieved. The quality of the study was assessed using the Newcastle-Ottawa Scale (NOS) tool for observational studies and Revised Cochrane risk-of-bias tool for randomized trials (RoB 2) for clinical trial studies. Statistical analysis was done using Review Manager 5.4 software. A total of eight studies with 5778 COVID-19 patients were included in this meta-analysis. This meta-analysis showed that the administration of colchicine was associated with improvement of outcomes of COVID-19 [OR 0.43 (95% CI 0.34-0.55), p < 0.00001, I 2 = 0%, fixed-effect modelling] and its subgroup which comprised of reduction from severe COVID-19 [OR 0.44 (95% CI 0.31-0.63), p < 0.00001, I 2 = 0%, fixed-effect modelling] and reduction of mortality rate from COVID-19 [OR 0.43 (95% CI 0.32-0.58), p < 0.00001, I 2 = 0%, fixed-effect modelling]. Our study suggests the routine use of colchicine for treatment modalities of COVID-19 patients. More randomized clinical trial studies are still needed to confirm the results from this study.
Keywords: colchicine; coronavirus disease 2019; immune therapy; treatment.
【저자키워드】 Treatment, Coronavirus disease 2019, Colchicine, immune therapy, 【초록키워드】 COVID-19, Treatment, coronavirus disease, Meta-analysis, Inflammatory diseases, Inflammation, review, randomized clinical trial, Coronavirus disease 2019, Efficacy, Europe, clinical trial, severe COVID-19, randomized trial, outcome, database, observational studies, observational study, immune, Colchicine, mortality rate, COVID-19 patients, administration, Analysis, statistical analysis, COVID-19 patient, reduction, randomized trials, Newcastle-Ottawa Scale, 95% CI, article, offer, effective, benefit, colchicine treatment, shown, eight, searched, reducing, was done, NOS, PMC, retrieved, RoB 2, the Newcastle-Ottawa Scale, 【제목키워드】 Treatment, Meta-analysis, Coronavirus disease 2019, systematic review, outcome, Colchicine, IMPROVE,