Abstract
This systematic review and meta-analysis examined the efficacy of sofosbuvir-based antiviral treatment against COVID-19 (coronavirus disease 2019). PubMed, Embase, Cochrane Central Register of Controlled Trials and ClinicalTrials.gov were searched from inception to 15 August 2021. Studies comparing the clinical efficacy and safety of sofosbuvir-based antiviral regimens (study group) with other antivirals or standard of care (control group) in patients with COVID-19 were included. Overall, 687 patients with COVID-19 were included, of which 377 patients received sofosbuvir-based treatment. Mortality was lower in the study group than in the control group [odds ratio (OR) = 0.49, 95% confidence interval (CI) 0.30-0.79; I 2 = 0%]. The overall clinical recovery rate was higher in the study group than in the control group (OR = 1.82, 95% CI 1.20-2.76; I 2 = 28%). The study group presented a lower requirement for mechanical ventilation (OR = 0.33, 95% CI 0.13-0.89; I 2 = 0%) and intensive care unit admission (OR = 0.42, 95% CI 0.25-0.70; I 2 = 0%) than the control group. Furthermore, the study group exhibited a shorter hospital length of stay [mean deviation (MD), -1.49, 95% CI -2.62 to -0.37; I 2 = 56%] and recovery time (MD, -1.34, 95% CI -2.29 to -0.38; I 2 = 46%) than the control group. Sofosbuvir-based treatment may help reduce mortality in patients with COVID-19 and improve associated clinical outcomes. Furthermore, sofosbuvir-based treatment was as safe as the comparator in patients with COVID-19. However, further large-scale studies are warranted to validate these findings.
Keywords: COVID-19; ICU; Mortality; SARS-CoV-2; Sofosbuvir.
【저자키워드】 COVID-19, SARS-CoV-2, Mortality, ICU, Sofosbuvir., 【초록키워드】 Treatment, coronavirus disease, Meta-analysis, Coronavirus disease 2019, Efficacy, intensive care, Antiviral, mechanical ventilation, hospital, systematic review, Antiviral treatment, sofosbuvir, clinical outcomes, clinical recovery, controlled trials, Patient, Admission, intensive care unit admission, Clinical efficacy, Recovery time, Odds ratio, Safe, regimen, Standard of care, control group, study group, 95% CI, 95% confidence interval, help, ClinicalTrials, comparator, inception, deviation, mean deviation, reduce mortality, IMPROVE, examined, exhibited, searched, Controlled, patients with COVID-19, the study group, 【제목키워드】 Treatment, randomised controlled trial, systematic review, Clinical outcome, Patient, Effect,