Abstract
Aim: This meta-analysis aimed to assess the usefulness of colchicine in patients with COVID-19.
Methods: PubMed, Web of Science, Ovid MEDLINE, the Cochrane Library, Embase, and Clinicaltrials.gov were searched for relevant randomised controlled trials (RCTs) published between database inception and November 12, 2021. Only RCTs that compared the clinical efficacy and safety of colchicine with other alternative treatments or placebos in patients with COVID-19 were included.
Results: Overall, 7 RCTs involving 16,024 patients were included; 7,794 patients were in the study group receiving colchicine and 8,230 were in the control group receiving placebo or standard treatment. The study and control groups had similar risk of mortality (odds ratio [OR], 1.00; 95% CI, 0.91-1.09; I 2 = 0%). No significant difference was observed between the study and control groups in terms of the need for non-invasive ventilation (OR, 0.92; 95% CI, 0.83-1.03; I 2 = 0%), the need for mechanical ventilation (OR, 0.64; 95% CI, 0.32-1.32; I 2 = 58%), and length of hospital stay (mean difference, -0.42 days; 95% CI, -1.95 to 1.11; I 2 = 62%). In addition, colchicine was associated with significantly higher risks of gastrointestinal adverse events (OR, 1.81; 95% CI, 1.56-2.11; I 2 = 0%) and diarrhoea (OR, 2.12; 95% CI, 1.75-2.56; I 2 = 9%).
Conclusions: Colchicine does not improve clinical outcomes in patients with COVID-19, so it did not support the additional use of colchicine in the treatment of patients with COVID-19.Key messageColchicine could not reduce the mortality of patients with COVID-19.No significant difference was observed between the colchicine and comparators in terms of the need for non-invasive ventilation, need for mechanical ventilation, and length of hospital stay.Colchicine was associated with a higher risk of gastrointestinal adverse events.
Keywords: COVID-19; Colchicine; SARS-CoV-2; mechanical ventilation; mortality; non-invasive ventilation.
【저자키워드】 COVID-19, SARS-CoV-2, Mortality, mechanical ventilation, Colchicine, non-invasive ventilation., 【초록키워드】 Treatment, Meta-analysis, randomised controlled trial, mechanical ventilation, hospital, risk, database, RCT, clinical outcomes, adverse events, adverse event, Patient, non-invasive ventilation, Colchicine, Placebo, RCTs, Clinical efficacy, Odds ratio, Hospital stay, diarrhoea, Support, Web of Science, significant difference, control group, study group, higher risk, 95% CI, no significant difference, standard treatment, ClinicalTrials, Cochrane Library, mean difference, OVID, placebos, addition, receiving, searched, significantly higher, improve clinical outcome, not reduce, patients with COVID-19, the study group, 【제목키워드】 Meta-analysis, randomised controlled trial, systematic review, outcome, Patient, Effect,