Analysis of mutations I117V and I117M in the neuraminidase of influenza A pandemic (H1N1) 2009 viruses showed that I117V confers a mild reduction in oseltamivir sensitivity and has a synergistic effect of further increasing resistance when combined with H275Y. Contrary to recent reports, the I117M mutation does not alter oseltamivir sensitivity.
All Keywords
【저자키워드】 viruses, oseltamivir, Influenza, mutations, drug resistance, synergistic, zanamivir, neuraminidase inhibitor, Peramivir, H275Y, I117V, I117M, NAI,
【저자키워드】 viruses, oseltamivir, Influenza, mutations, drug resistance, synergistic, zanamivir, neuraminidase inhibitor, Peramivir, H275Y, I117V, I117M, NAI,