Abstract
The coronavirus disease 2019 (COVID-19) pandemic spread globally in the beginning of 2020. At present, predictors of severe disease and the efficacy of different treatments are not well understood. We conducted a systematic review and meta-analysis of all published studies up to 15 March 2020, which reported COVID-19 clinical features and/or treatment outcomes. Forty-five studies reporting 4203 patients were included. Pooled rates of intensive care unit (ICU) admission, mortality, and acute respiratory distress syndrome (ARDS) were 10.9%, 4.3%, and 18.4%, respectively. On meta-regression, ICU admission was predicted by increased leukocyte count (P < .0001), alanine aminotransferase (P = .024), and aspartate transaminase (P = .0040); elevated lactate dehydrogenase (LDH) (P < .0001); and increased procalcitonin (P < .0001). ARDS was predicted by elevated LDH (P < .0001), while mortality was predicted by increased leukocyte count (P = .0005) and elevated LDH (P < .0001). Treatment with lopinavir-ritonavir showed no significant benefit in mortality and ARDS rates. Corticosteroids were associated with a higher rate of ARDS (P = .0003).
Keywords: COVID-19; coronavirus; risk factor; severe; treatment.
【저자키워드】 COVID-19, Treatment, coronavirus, risk factor, severe, 【초록키워드】 Treatment, coronavirus disease, Meta-analysis, Respiratory distress syndrome, Coronavirus disease 2019, Efficacy, ARDS, Corticosteroids, pandemic, Mortality, intensive care, acute respiratory distress syndrome, Lopinavir, Ritonavir, intensive care unit, LDH, systematic review, risk, procalcitonin, risk factor, lactate dehydrogenase, meta-regression, ICU, Spread, outcomes, Patient, ICU admission, predictor, Admission, clinical feature, acute respiratory distress, Lactate, Lopinavir-ritonavir, severe disease, respiratory distress, alanine aminotransferase, leukocyte, syndrome, aspartate, Alanine, Aspartate transaminase, present, pandemic spread, elevated lactate dehydrogenase, benefit, Pooled rates, predicted, reported, elevated, conducted, 【제목키워드】 review, Factor,