Under the Emergency Use Authorization issued in April 2009, 1 oseltamivir can be used to treat 2009 influenza A (2009 H1N1) virus infection in children <1 year of age. No data exist on dosing oseltamivir in premature babies. A hospital health care worker inadvertently exposed 32 neonatal intensive care unit babies to 2009 H1N1; a protocol was expeditiously implemented to collect samples for pharmacokinetics and dose evaluation. Results suggest 1.0 mg/kg/dose twice daily in premature babies produces oseltamivir carboxylate exposures similar to older children receiving 3.0 mg/kg/dose twice daily. These results provide initial guidance on dosing oseltamivir in this vulnerable population.
All Keywords
【저자키워드】 oseltamivir, pharmacokinetics, influenza A, 2009 H1N1, Premature Neonates,
【저자키워드】 oseltamivir, pharmacokinetics, influenza A, 2009 H1N1, Premature Neonates,