Pre-pandemic intravenous immunoglobulin (IVIG) and sera from Kawasaki disease (KD) patients treated with this IVIG were analyzed for 2009 H1N1-specific microneutralization and hemagglutination inhibition antibodies. All six different IVIG preparations tested had significant levels of cross-reactive specific antibody at a concentration of 2.0 g/dL of immunoglobulin. Sera from 18/19 of KD patients had significant increases of cross-reactive specific antibody after 2.0 g/kg of pre-pandemic IVIG. These results suggest a role for adjunctive IVIG therapy for severe and/or drug-resistant 2009 H1N1 virus and other highly antigenically drifted influenza strains, particularly in the immunocompromised.
All Keywords
【저자키워드】 neutralizing antibody, Intravenous immunoglobulin, influenza A, Kawasaki disease, 2009 H1N1,
【저자키워드】 neutralizing antibody, Intravenous immunoglobulin, influenza A, Kawasaki disease, 2009 H1N1,