In an observational cohort study, we found that adults hospitalized for oseltamivir‐resistant (H275Y) seasonal H1N1 influenza ( n = 46) were older than those infected with oseltamivir‐susceptible strains ( n = 31) [74(IQR 59–83) versus 64(IQR 48–76) years; P = 0·045], and most had major comorbidities (78% versus 65%). Disease severity and clinical outcomes were comparable between the two groups: radiographic pneumonia 40–42%, supplemental oxygen use 47–48%, critical illness 11–13%, median duration of hospitalization 5–6 days, death rate 6–9%. Failure to receive effective antiviral therapy was associated with progression to critical illness (23% versus 0%, P = 0·016) and death (20% versus 0%, P = 0·033) in hospitalized patients with seasonal H1N1 influenza.
【저자키워드】 oseltamivir, H275Y, seasonal influenza A(H1N1) virus,