Abstract
Numerous molecular mechanisms are being examined in an attempt to discover disease-modifying drugs to slow down the underlying neurodegeneration in Alzheimer’s disease. Recent studies have shown the beneficial effects of epidermal growth factor receptor inhibitors on the enhancement of behavioral and pathological sequelae in Alzheimer’s disease. Despite the promising effects of epidermal growth factor receptor inhibitors in Alzheimer’s disease, there is no irrefutable neuroprotective evidence in well-established animal models using epidermal growth factor receptor inhibitors due to many un-explored downstream signaling pathways. This caused controversy about the potential involvement of epidermal growth factor receptor inhibitors in any prospective clinical trial. In this review, the mystery beyond the under-investigation of epidermal growth factor receptor in Alzheimer’s disease will be discussed. Furthermore, their molecular mechanisms in neurodegeneration will be explained. Also, we will shed light on SARS-COVID-19 induced neurological manifestations mediated by epidermal growth factor modulation. Finally, we will discuss future perspectives and under-examined epidermal growth factor receptor downstream signaling pathways that warrant more exploration. We conclude that epidermal growth factor receptor inhibitors are novel effective therapeutic approaches that require further research in attempts to be repositioned in the delay of Alzheimer’s disease progression.
Keywords: Alzheimer’s disease; autophagy; drug re-positioning; epidermal growth factor receptor; human epidermal growth factor receptor-2; neurodegenerative diseases; neuroinflammation; oxidative stress; tyrosine kinase inhibitors.
【저자키워드】 oxidative stress, autophagy, Alzheimer’s disease, Tyrosine kinase inhibitors., breath, Neuroinflammation, Neurodegenerative diseases, drug re-positioning, epidermal growth factor receptor, human epidermal growth factor receptor-2, 【초록키워드】 animal model, drug, oxidative stress, molecular mechanism, autophagy, Alzheimer’s disease, Disease progression, Research, Neuroinflammation, kinase inhibitors, Alzheimer's disease, neurological manifestations, positioning, receptor, disease, signaling pathways, neurodegeneration, Evidence, epidermal growth factor, tyrosine, tyrosine kinase inhibitors, Prospective clinical trial, modulation, Perspective, growth factor, enhancement, Effect, neurological manifestation, recent, effective, downstream signaling pathways, oxidative, shown, examined, caused, explained, therapeutic approach, Numerous, neurodegenerative, epidermal, downstream signaling pathway, receptor inhibitor, 【제목키워드】 receptor, disease, mechanism, growth factor, Effect, epidermal,