Abstract
Although coronavirus disease 2019 seems to be the leading topic in research number of outstanding studies have been published in the field of aorta and peripheral vascular diseases likely affecting our clinical practice in the near future. This review article highlights key research on vascular diseases published in 2020. Some studies have shed light in the pathophysiology of aortic aneurysm and dissection suggesting a potential role for kinase inhibitors as new therapeutic options. A first proteogenomic study on fibromuscular dysplasia (FMD) revealed a promising novel disease gene and provided proof-of-concept for a protein/lipid-based FMD blood test. The role of NADPH oxidases in vascular physiology, and particularly endothelial cell differentiation, is highlighted with potential for cell therapy development. Imaging of vulnerable plaque has been an intense field of research. Features of plaque vulnerability on magnetic resonance imaging as an under-recognized cause of stroke are discussed. Major clinical trials on lower extremity peripheral artery disease have shown added benefit of dual antithrombotic (aspirin plus rivaroxaban) treatment.
Keywords: Antithrombotics; Aorta; COVID; Peripheral artery disease; Venous thromboembolism.
【저자키워드】 Venous Thromboembolism, COVID, breath, Antithrombotics, Aorta, Peripheral artery disease, 【초록키워드】 Treatment, coronavirus disease, Coronavirus disease 2019, clinical trial, therapy, Cell therapy, magnetic resonance imaging, stroke, Venous Thromboembolism, pathophysiology, imaging, Research, Thromboembolism, kinase inhibitors, Aspirin, disease, Blood, Clinical practice, blood test, 2019, therapeutic options, Endothelial cell, Kinase inhibitor, Antithrombotic, NADPH oxidase, Aorta, Peripheral artery disease, vascular diseases, vascular disease, Major, rivaroxaban, Topic, Vascular, lower extremity, proof, NADPH, Dissection, plaque, aortic aneurysm, peripheral, benefit, Cell, highlight, fibromuscular dysplasia, shown, provided, added, affecting, 【제목키워드】 cardiovascular disease, Research, Progress,