Abstract
The angiotensin-converting enzyme 2 (ACE2) is the receptor for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It is highly expressed in adipose tissue, possibly associated with progression to severe coronavirus disease 2019 (COVID-19) in obese subjects. We searched the Gene Expression Omnibus (GEO) and reanalyzed the GSE59034 containing microarray data from subcutaneous white adipose tissue (sWAT) biopsies from 16 women before and 2 years after RYGB, and 16 controls matched by sex, age, and BMI. After RYGB, there was a significant decrease in sWAT ACE2 gene expression (logFC=-0.4175, P=0.0015). Interestingly, after RYGB the sWAT ACE2 gene expression was significantly lower than in non-obese matched controls (LogFC=-0.32875, P=0.0014). Our data adds to the well-known benefits of RYGB, a potential protective mechanism against COVID-19.
Keywords: ACE-2; Bariatric surgery; COVID-19; Obesity.
【저자키워드】 COVID-19, obesity, ACE-2, Bariatric surgery, 【초록키워드】 coronavirus disease, SARS-CoV-2, Coronavirus disease 2019, ACE2, coronavirus, obesity, Sex, progression, severe acute respiratory syndrome Coronavirus, angiotensin-converting enzyme 2, biopsies, Control, Microarray, age, receptor, women, BMI, expression, Adipose tissue, Angiotensin-converting enzyme, angiotensin, Bariatric surgery, biopsy, ACE2 gene, protective mechanism, acute respiratory syndrome, acute respiratory syndrome coronavirus, tissue, acute respiratory syndrome coronavirus 2, severe coronavirus disease, obese, significant decrease, Gene Expression Omnibus, significantly lower, adipose, benefit, SWAT, logFC, microarray data, searched, subjects, expressed, GEO, 【제목키워드】 ACE2, Subcutaneous, white, bypass, Against, Gastric,