Abstract
COVID-19 pandemic caused by the Severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2) has inflicted a global health challenge. Although the overwhelming escalation of mortality seen during the initial phase of the pandemic has reduced, emerging variants of SARS-CoV-2 continue to impact communities worldwide. Several studies have highlighted the association of gene specific epigenetic modifications in host cells with the pathogenesis and severity of the disease. Therefore, alongside the investigations into the virology and pathogenesis of SARS-CoV-2 infection, understanding the epigenetic mechanisms related to the disease is crucial for the rational design of effective targeted therapies. Here, we discuss the interaction of SARS-CoV-2 with the various epigenetic regulators and their subsequent contribution to the risk of disease severity and dysfunctional immune responses. Finally, we also highlight the use of epigenetically targeted drugs for the potential therapeutic interventions capable of eliminating viral infection and/or build effective immunity against it.
Keywords: Anti-viral immune response; DNA methylation; Epigenetics; Histone modification; MicroRNA; SARS-CoV-2 infection.
【저자키워드】 microRNA, epigenetics, SARS-CoV-2 infection., DNA methylation, Anti-viral immune response, Histone modification, 【초록키워드】 COVID-19, severe acute respiratory syndrome coronavirus 2, SARS-CoV-2, viral infection, coronavirus, pandemic, Pathogenesis, Virology, Mortality, Immunity, SARS-COV-2 infection, severity, disease severity, microRNA, Infection, risk, drug, severe acute respiratory syndrome Coronavirus, epigenetics, immune, DNA, Health, immune responses, SARS- CoV-2, Community, DNA methylation, Epigenetic, mechanism, Therapies, association, histone, Interaction, Escalation, host cells, host cell, acute respiratory syndrome, acute respiratory syndrome coronavirus, therapeutic intervention, epigenetic regulator, Modification, pathogenesis of SARS-CoV-2, variants of SARS-CoV-2, effective, highlight, initial, caused, subsequent, the disease, reduced, eliminating, build, 【제목키워드】 SARS CoV-2, Infection, understanding, Epigenetic, mechanism, therapeutic approach,