Ocular complications can occur from Mpox infection and are increasingly being reported, with the rise in worldwide cases. There are few reports of Mpox outside of endemic areas in healthy children. We describe a healthy girl with Mpox who presented with ocular symptoms after experiencing trauma to the eye; this case highlights a pediatric case of Mpox localized to the eye and periorbital region. In the absence of a prodromal phase, the ocular signs and symptoms were initially thought to represent more common, benign etiologies. This case underscores the importance of considering Mpox, even in the absence of known exposures or in the setting of an atypical presentation.
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