Abstract
The extensive sequence data generated from SARS-CoV-2 during the 2020 pandemic has facilitated the study of viral genome evolution over a brief period of time. This has highlighted instances of directional mutation pressures exerted on the SARS-CoV-2 genome from host antiviral defense systems. In this brief review we describe three such human defense mechanisms, the apolipoprotein B mRNA editing catalytic polypeptide-like proteins (APOBEC), adenosine deaminase acting on RNA proteins (ADAR), and reactive oxygen species (ROS), and discuss their potential implications on SARS-CoV-2 evolution.
Keywords: ADAR; APOBEC; Genome editing; ROS; SARS-CoV-2; Virus evolution.
All Keywords
【저자키워드】 SARS-CoV-2, Virus evolution, APOBEC, ROS, ADAR, Genome editing, 【초록키워드】 Evolution, pandemic, Mutation, Antiviral, Virus evolution, oxygen, RNA, Protein, Viral, SARS-CoV-2 genome, mRNA, Apolipoprotein B, APOBEC, ADAR, SARS-CoV-2 evolution, mechanisms, adenosine, reactive oxygen species, viral genome, defense mechanisms, adenosine deaminase, sequence, Defense, instances, Host, implication, facilitated, instance, directional, catalytic, reactive oxygen specy, acting, the SARS-CoV-2 genome, 【제목키워드】 the SARS-CoV-2 genome,
【저자키워드】 SARS-CoV-2, Virus evolution, APOBEC, ROS, ADAR, Genome editing, 【초록키워드】 Evolution, pandemic, Mutation, Antiviral, Virus evolution, oxygen, RNA, Protein, Viral, SARS-CoV-2 genome, mRNA, Apolipoprotein B, APOBEC, ADAR, SARS-CoV-2 evolution, mechanisms, adenosine, reactive oxygen species, viral genome, defense mechanisms, adenosine deaminase, sequence, Defense, instances, Host, implication, facilitated, instance, directional, catalytic, reactive oxygen specy, acting, the SARS-CoV-2 genome, 【제목키워드】 the SARS-CoV-2 genome,
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2020년 대유행 동안 SARS-CoV-2에서 생성된 광범위한 서열 데이터는 짧은 기간 동안 바이러스 게놈 진화 연구를 촉진했습니다. 이것은 숙주 항바이러스 방어 시스템에서 SARS-CoV-2 게놈에 가해지는 방향성 돌연변이 압력의 사례를 강조했습니다. 이 간략한 리뷰에서 우리는 세 가지 인간 방어 메커니즘, 즉 아포지단백 B mRNA 편집 촉매성 폴리펩타이드 유사 단백질(APOBEC), RNA 단백질에 작용하는 아데노신 데아미나제(ADAR) 및 반응성 산소종(ROS)에 대해 설명하고 이들의 잠재적 영향에 대해 논의합니다. SARS-CoV-2 진화.
{{ 키워드: }} ADAR; 아포벡; 게놈 편집; 로스; 사스 코로나바이러스 2; 바이러스 진화.