Abstract
The vaccine for the coronavirus disease 2019 (COVID-19) has been reported to potentially cause or worsen diabetes. A 73-year-old Japanese woman received two doses of Moderna COVID-19 vaccine. Four weeks after the second vaccination, her glycemic control began to deteriorate, and 8 weeks after the second vaccination, the patient was diagnosed with new-onset type 1 diabetes that was strongly positive for autoantibodies and showed a disease-susceptible human leukocyte antigen haplotype, DRB1*04:05:01-DQB1*04:01:01. The glucagon stimulation test suggested an insulin-dependent state, and induction of intensive insulin therapy brought about fair glycemic control. The time period from the COVID-19 vaccination to the development of type 1 diabetes was relatively longer than to the onset or exacerbation of type 2 diabetes, as previously reported, suggesting the complicated immunological mechanisms for the destruction of β-cells associated with the vaccination. In recipients with the disease-susceptible haplotypes, one should be cautious about autoimmune responses for several months after the vaccination.
Keywords: COVID-19; Type 1 diabetes; Vaccine.
【저자키워드】 COVID-19, Type 1 diabetes, vaccine., 【초록키워드】 coronavirus disease, Type 1 diabetes, Coronavirus disease 2019, Vaccine, COVID-19 vaccine, vaccination, human leukocyte antigen, haplotypes, diabetes, Antigen, type 2 diabetes, COVID-19 vaccination, autoantibodies, Japanese, insulin, Intensive, glycemic control, Moderna, Haplotype, dose, immunological mechanism, Autoimmune response, autoantibody, β-cells, leukocyte, Exacerbation, Insulin therapy, glucagon, stimulation test, recipients, second vaccination, DRB1, positive, recipient, DQB1, destruction, autoimmune responses, reported, the patient, diagnosed, suggested, diabete, deteriorate, β-cell, 【제목키워드】 Case report, diabete,