Abstract
Acute Respiratory Distress Syndrome (ARDS) is a form of respiratory failure in human. The number of deaths caused by SARS-CoV-2 infection inducing this severe pneumonia (ARDS) is relatively high. In fact, COVID-19 might get worsen in ARDS and provoke respiratory failure. A better understood of ARDS key features and the pathophysiological injuries of the pulmonary parenchyma are linked to lessons learned from previous severe diseases associated previous coronaviruses outbreaks (especially SARS-CoV and MERS-CoV) and more the ongoing SARS-CoV-2. The ARDS mechanism includes a diffuse alveolar damage associated disruption of alveolar capillary membrane, pulmonary edema, damaged endothelium and increased permeability. A diffuse inflammation, with acute onset, on the lung tissue accompanied by release of biochemical signal and inflammatory mediators (TNFα, IL-1 and IL-6) leading to hypoxemia, low PaO 2 /FiO 2 ratio and the chest radiological expression of bilateral infiltrates in ARDS. The ongoing outbreak could lead to a better understood of ARDS pathophysiology and prognostic. An overview is also highlighted about the seven coronaviruses proved to infect human especially those having ability to cause severe disease SARS-CoV, MERS-CoV and SARS-CoV-2. In this review, we focused on the major pathological mechanisms leading to the ARDS development as a result of viral infection, severe COVID-19 worsening. Communicated by Ramaswamy H. Sarma.
Keywords: ACE2; ARDS; COVID-19; SARS-CoV-2; coronavirus; pathophysiology.
【저자키워드】 COVID-19, SARS-CoV-2, ACE2, ARDS, coronavirus, Pathophysiology., 【초록키워드】 Inflammation, Respiratory distress syndrome, viral infection, ARDS, Respiratory failure, severe COVID-19, acute respiratory distress syndrome, SARS-CoV, IL-6, SARS-COV-2 infection, Human, MERS-CoV, Endothelium, pathophysiology, outbreak, Hypoxemia, edema, death, membrane, Pulmonary edema, Diffuse alveolar damage, severe pneumonia, prognostic, respiratory, expression, mechanism, IL-1, Inflammatory mediators, Injury, severe disease, Disruption, respiratory distress, alveolar damage, biochemical, worsening, lung tissue, TNFα, pulmonary parenchyma, infect, alveolar capillary, feature, inflammatory mediator, pathological mechanism, Seven, diffuse inflammation, caused, include, coronavirus, damaged, accompanied, chest radiological, PaO, pathophysiological, provoke, 【제목키워드】 distress, life threatening,