Abstract
The coronavirus disease-2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is challenging global health and economic systems. In some individuals, COVID-19 can cause a wide array of symptoms, affecting several organs, such as the lungs, heart, bowels, kidneys and brain, causing multiorgan failure, sepsis and death. These effects are related in part to direct viral infection of these organs, immunological deregulation, a hypercoagulatory state and the potential for development of cytokine storm syndrome. Since the appearance of COVID-19 is recent, the long-term effects on the health of recovered patients remain unknown. In this review, we focused on current evidence of the mechanisms of DNA damage mediated by coronaviruses. Data supports that these viruses can induce DNA damage, genomic instability, and cell cycle deregulation during their replication in mammalian cells. Since the induction of DNA damage and aberrant DNA repair mechanisms are related to the development of chronic diseases such as cancer, diabetes, neurodegenerative disorders, and atherosclerosis, it will be important to address similar effects and outcomes in recovered COVID-19 patients.
Keywords: COVID-19; DNA damage; DNA repair; SARS-CoV-2.
【저자키워드】 COVID-19, SARS-CoV-2., DNA damage, DNA repair, 【초록키워드】 coronavirus disease, SARS-CoV-2, viral infection, Coronaviruses, coronavirus, Cancer, Sepsis, severe acute respiratory syndrome coronavirus-2, Cytokine storm syndrome, diabetes, outcome, severe acute respiratory syndrome Coronavirus, Symptoms, cell cycle, Brain, chronic disease, kidney, DNA damage, Replication, Severe acute respiratory syndrome, DNA, Health, heart, Lungs, Atherosclerosis, death, recovered patients, genomic, mechanism, Coronavirus-2, Evidence, Recovered COVID-19 patients, DNA repair, neurodegenerative disorders, evidence of, in some, Support, Chronic diseases, acute respiratory syndrome, these viruses, acute respiratory syndrome coronavirus, appearance, acute respiratory syndrome coronavirus-2, multiorgan failure, kidneys, organs, mammalian cells, deregulation, direct viral infection, Effect, immunological, Cell, recovered patient, caused, virus, induce, individuals, affecting, DNA repair mechanism,