Abstract
Coronavirus disease 2019 (COVID-19) is an illness caused by a novel coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Mutations in the genetic coding and the variations in the spike proteins are critical for the virus’s mechanism of facilitating fusion with the human host, making the disease more severe. Recent research indicates that comorbidities including diabetes, hypertension, renal disease, heart failure, and atherosclerosis play a significant role in the severity and high mortality rates of (COVID-19), suggesting that perhaps the metabolic syndrome and its components are associated with COVID-19 morbidity. Primarily, angiotensin-converting enzyme 2 (ACE2) receptor is identified as the entrance receptor of SARS-CoV-2. Increased ACE2 expression, endothelial dysfunction plays a vital role in the progression and severity of complications developed due to COVID-19. In this review, we will discuss the association and management of cardiorenal disease and COVID-19.
【초록키워드】 COVID-19, coronavirus disease, SARS-CoV-2, Coronavirus disease 2019, ACE2, coronavirus, severity, Variation, Genetic, Comorbidities, Comorbidity, progression, diabetes, severe acute respiratory syndrome Coronavirus, virus, hypertension, angiotensin-converting enzyme 2, Endothelial dysfunction, Novel coronavirus, heart failure, metabolic syndrome, management, Atherosclerosis, morbidity, Research, Complication, variations, receptor, renal disease, fusion, ACE2 expression, disease, Critical, mechanism, association, Angiotensin-converting enzyme, angiotensin, Spike proteins, Cardiorenal Disease, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, enzyme, coding, syndrome, human host, component, renal, high mortality rate, recent, caused, the disease, indicate, the spike protein, Increased, with COVID-19, 【제목키워드】 COVID-19,